Ghent, Belgium
Belgium's third-largest city, Ghent is located at the confluence of the Lys and Scheldt rivers. Known as the "City of Art," it's a town created by merchants who prospered and poured their riches into the arts after amassing great wealth due to the wool trade. One of Ghent's richest citizens commissioned two luminaries of the Northern Renaissance, Jan and Hubert Van Eyck to paint "Adoration of the Mystic Lamb." The painting took over six years to complete and was donated to a church in the city.